Retatrutide

Retatrutide is like the next step beyond Mounjaro for weight loss.

It activates three hormone receptors at once:

GLP-1 → makes you less hungry and slows digestion.
GIP → improves how your body handles insulin and can add to the appetite/weight-loss effect.
Glucagon → increases energy expenditure and encourages your body to use stored fat.

So, in simple terms:

Eat less + feel fuller + improve blood sugar + potentially burn/use more stored energy = significant weight loss.

That's why it's getting so much attention. In the latest Phase 3 data, the highest dose produced around 28% average weight loss at 80 weeks in one obesity trial.

The big difference from Mounjaro/tirzepatide is:

Mounjaro = GIP + GLP-1
Retatrutide = GIP + GLP-1 + glucagon